Hydreia
Category
Hydreia Brand names, Hydreia Analogs
Hydreia Brand Names Mixture
Hydreia Chemical_Formula
CH4N2O2
Hydreia RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Hydreia fda sheet
Hydreia msds (material safety sheet)
Hydreia Synthesis Reference
No information avaliable
Hydreia Molecular Weight
76.0547 g/mol
Hydreia Melting Point
142-146 oC
Hydreia H2O Solubility
1E+006 mg/L
Hydreia State
Solid
Hydreia LogP
-1.432
Hydreia Dosage Forms
Capsule
Hydreia Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydreia Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Hydreia Absorption
Well absorbed from the gastrointestinal tract.
Hydreia side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hydreia Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Hydreia Organisms Affected
Humans and other mammals
