Litaler
Category
Litaler Brand names, Litaler Analogs
Litaler Brand Names Mixture
Litaler Chemical_Formula
CH4N2O2
Litaler RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Litaler fda sheet
Litaler msds (material safety sheet)
Litaler Synthesis Reference
No information avaliable
Litaler Molecular Weight
76.0547 g/mol
Litaler Melting Point
142-146 oC
Litaler H2O Solubility
1E+006 mg/L
Litaler State
Solid
Litaler LogP
-1.432
Litaler Dosage Forms
Capsule
Litaler Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Litaler Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Litaler Absorption
Well absorbed from the gastrointestinal tract.
Litaler side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Litaler Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Litaler Organisms Affected
Humans and other mammals
