Carbamohydroxamic Acid
Category
Carbamohydroxamic Acid Brand names, Carbamohydroxamic Acid Analogs
Carbamohydroxamic Acid Brand Names Mixture
Carbamohydroxamic Acid Chemical_Formula
CH4N2O2
Carbamohydroxamic Acid RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Carbamohydroxamic Acid fda sheet
Carbamohydroxamic Acid msds (material safety sheet)
Carbamohydroxamic Acid Synthesis Reference
No information avaliable
Carbamohydroxamic Acid Molecular Weight
76.0547 g/mol
Carbamohydroxamic Acid Melting Point
142-146 oC
Carbamohydroxamic Acid H2O Solubility
1E+006 mg/L
Carbamohydroxamic Acid State
Solid
Carbamohydroxamic Acid LogP
-1.432
Carbamohydroxamic Acid Dosage Forms
Capsule
Carbamohydroxamic Acid Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Carbamohydroxamic Acid Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Carbamohydroxamic Acid Absorption
Well absorbed from the gastrointestinal tract.
Carbamohydroxamic Acid side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Carbamohydroxamic Acid Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Carbamohydroxamic Acid Organisms Affected
Humans and other mammals
