Carbamohydroxyamic Acid
Category
Carbamohydroxyamic Acid Brand names, Carbamohydroxyamic Acid Analogs
Carbamohydroxyamic Acid Brand Names Mixture
Carbamohydroxyamic Acid Chemical_Formula
CH4N2O2
Carbamohydroxyamic Acid RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Carbamohydroxyamic Acid fda sheet
Carbamohydroxyamic Acid msds (material safety sheet)
Carbamohydroxyamic Acid Synthesis Reference
No information avaliable
Carbamohydroxyamic Acid Molecular Weight
76.0547 g/mol
Carbamohydroxyamic Acid Melting Point
142-146 oC
Carbamohydroxyamic Acid H2O Solubility
1E+006 mg/L
Carbamohydroxyamic Acid State
Solid
Carbamohydroxyamic Acid LogP
-1.432
Carbamohydroxyamic Acid Dosage Forms
Capsule
Carbamohydroxyamic Acid Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Carbamohydroxyamic Acid Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Carbamohydroxyamic Acid Absorption
Well absorbed from the gastrointestinal tract.
Carbamohydroxyamic Acid side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Carbamohydroxyamic Acid Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Carbamohydroxyamic Acid Organisms Affected
Humans and other mammals
