Droxia
Category
Droxia Brand names, Droxia Analogs
Droxia Brand Names Mixture
Droxia Chemical_Formula
CH4N2O2
Droxia RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Droxia fda sheet
Droxia msds (material safety sheet)
Droxia Synthesis Reference
No information avaliable
Droxia Molecular Weight
76.0547 g/mol
Droxia Melting Point
142-146 oC
Droxia H2O Solubility
1E+006 mg/L
Droxia State
Solid
Droxia LogP
-1.432
Droxia Dosage Forms
Capsule
Droxia Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Droxia Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Droxia Absorption
Well absorbed from the gastrointestinal tract.
Droxia side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Droxia Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Droxia Organisms Affected
Humans and other mammals
