Ureaphil
Category
Ureaphil Brand names, Ureaphil Analogs
Ureaphil Brand Names Mixture
Ureaphil Chemical_Formula
CH4N2O2
Ureaphil RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Ureaphil fda sheet
Ureaphil msds (material safety sheet)
Ureaphil Synthesis Reference
No information avaliable
Ureaphil Molecular Weight
76.0547 g/mol
Ureaphil Melting Point
142-146 oC
Ureaphil H2O Solubility
1E+006 mg/L
Ureaphil State
Solid
Ureaphil LogP
-1.432
Ureaphil Dosage Forms
Capsule
Ureaphil Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Ureaphil Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Ureaphil Absorption
Well absorbed from the gastrointestinal tract.
Ureaphil side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Ureaphil Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Ureaphil Organisms Affected
Humans and other mammals
