Hydura
Category
Hydura Brand names, Hydura Analogs
Hydura Brand Names Mixture
Hydura Chemical_Formula
CH4N2O2
Hydura RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Hydura fda sheet
Hydura msds (material safety sheet)
Hydura Synthesis Reference
No information avaliable
Hydura Molecular Weight
76.0547 g/mol
Hydura Melting Point
142-146 oC
Hydura H2O Solubility
1E+006 mg/L
Hydura State
Solid
Hydura LogP
-1.432
Hydura Dosage Forms
Capsule
Hydura Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydura Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Hydura Absorption
Well absorbed from the gastrointestinal tract.
Hydura side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hydura Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Hydura Organisms Affected
Humans and other mammals
