Blackburn_Compound
Category
Blackburn_Compound Brand names, Blackburn_Compound Analogs
Blackburn_Compound Brand Names Mixture
No information avaliable
Blackburn_Compound Chemical_Formula
C18H15Cl3N2O
Blackburn_Compound RX_link
http://www.rxlist.com/cgi/generic3/econazole.htm
Blackburn_Compound fda sheet
Blackburn_Compound msds (material safety sheet)
Blackburn_Compound Synthesis Reference
No information avaliable
Blackburn_Compound Molecular Weight
381.683 g/mol
Blackburn_Compound Melting Point
No information avaliable
Blackburn_Compound H2O Solubility
No information avaliable
Blackburn_Compound State
No information avaliable
Blackburn_Compound LogP
5.401
Blackburn_Compound Dosage Forms
Topical cream (1%); Suppository
Blackburn_Compound Indication
For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
Blackburn_Compound Pharmacology
Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Blackburn_Compound Absorption
After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Blackburn_Compound Toxicity
Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
Blackburn_Compound Patient Information
No information avaliable
Blackburn_Compound Organisms Affected
Yeast and other fungi
