2MDTP
Category
2MDTP Brand names, 2MDTP Analogs
2MDTP Brand Names Mixture
No information avaliable
2MDTP Chemical_Formula
C18H15Cl3N2O
2MDTP RX_link
http://www.rxlist.com/cgi/generic3/econazole.htm
2MDTP fda sheet
2MDTP msds (material safety sheet)
2MDTP Synthesis Reference
No information avaliable
2MDTP Molecular Weight
381.683 g/mol
2MDTP Melting Point
No information avaliable
2MDTP H2O Solubility
No information avaliable
2MDTP State
No information avaliable
2MDTP LogP
5.401
2MDTP Dosage Forms
Topical cream (1%); Suppository
2MDTP Indication
For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
2MDTP Pharmacology
Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
2MDTP Absorption
After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
2MDTP Toxicity
Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
2MDTP Patient Information
No information avaliable
2MDTP Organisms Affected
Yeast and other fungi
