Permastril
Category
Permastril Brand names, Permastril Analogs
Permastril Brand Names Mixture
No information avaliable
Permastril Chemical_Formula
C18H15Cl3N2O
Permastril RX_link
http://www.rxlist.com/cgi/generic3/econazole.htm
Permastril fda sheet
Permastril msds (material safety sheet)
Permastril Synthesis Reference
No information avaliable
Permastril Molecular Weight
381.683 g/mol
Permastril Melting Point
No information avaliable
Permastril H2O Solubility
No information avaliable
Permastril State
No information avaliable
Permastril LogP
5.401
Permastril Dosage Forms
Topical cream (1%); Suppository
Permastril Indication
For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
Permastril Pharmacology
Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Permastril Absorption
After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Permastril Toxicity
Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
Permastril Patient Information
No information avaliable
Permastril Organisms Affected
Yeast and other fungi
