MDHT
Category
MDHT Brand names, MDHT Analogs
MDHT Brand Names Mixture
No information avaliable
MDHT Chemical_Formula
C18H15Cl3N2O
MDHT RX_link
http://www.rxlist.com/cgi/generic3/econazole.htm
MDHT fda sheet
MDHT msds (material safety sheet)
MDHT Synthesis Reference
No information avaliable
MDHT Molecular Weight
381.683 g/mol
MDHT Melting Point
No information avaliable
MDHT H2O Solubility
No information avaliable
MDHT State
No information avaliable
MDHT LogP
5.401
MDHT Dosage Forms
Topical cream (1%); Suppository
MDHT Indication
For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
MDHT Pharmacology
Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Econazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
MDHT Absorption
After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
MDHT Toxicity
Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
MDHT Patient Information
No information avaliable
MDHT Organisms Affected
Yeast and other fungi
