Categoria
Hexanuret
Marchi,
Hexanuret
Analoghi
Hexanuret
Marchi miscela
No information avaliable
Hexanuret
Formula chimica
C5H4N4O
Hexanuret
RX link
http://www.rxlist.com/cgi/generic/allopur.htm
Hexanuret
FDA foglio
Hexanuret
DMS (foglio di materiale di sicurezza)
Hexanuret
Sintesi di riferimento
Robins, J. Am. Chem. Così. 78, 784 (1956)
Hexanuret
Peso molecolare
136.112 g/mol
Hexanuret
Temperatura di fusione
350 oC
Hexanuret
H2O Solubilita
569 mg / L
Hexanuret
Stato
Solid
Hexanuret
LogP
-0.177
Hexanuret
Forme di dosaggio
Compresse per somministrazione orale (100mg, 200mg e 300mg); iniezione
Hexanuret
Indicazione
Per il trattamento di iperuricemia associata a gotta primaria o secondaria.
Hexanuret
Farmacologia
Allopurinolo, un analogo strutturale della base purinica ipoxantina naturale, è utilizzato per prevenire la gotta e calcoli renali a causa sia di acido urico o di ossalato di calcio e per il trattamento di nefropatia da acido urico, iperuricemia, e alcuni tumori solidi.
Hexanuret
Assorbimento
Circa il 90% assorbito dal tratto gastrointestinale.
Hexanuret
Tossicita
LD50 = 214 mg / kg (nei topi)
Hexanuret
Informazioni paziente
Patients should be informed of the following:
- 1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the
first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips
or mouth.
- 2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit
of allopurinol may be delayed for two to six weeks.
- 3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
- 4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the
next scheduled time.
- 5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol,
sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should
follow the instructions of their physician.
- 6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in
activities where alertness is mandatory.
- 7. Patients may wish to take allopurinol after meals to minimize gastric irritation.
Hexanuret
Atto interessato organismi
Gli esseri umani e altri mammiferi