Purinol
Purinol Brand names, Purinol Analogs
- 7HP
- Adenock
- Ailural
- Allo-Puren
- Allopur
- Allopurinol Sodium
- Allopurinolum [Inn-Latin]
- Allozym
- Allural
- Aloprim
- Alopurinol [Inn-Spanish]
- Aloral
- Alositol
- Aluline
- Anoprolin
- Anzief
- Apo-Allopurinol
- Apulonga
- Apurin
- Apurol
- Atisuril
- Bleminol
- Bloxanth
- Caplenal
- Cellidrin
- Cosuric
- Dabrosin
- Dabroson
- Dura Al
- Embarin
- Epidropal
- Epuric
- Foligan
- Geapur
- Gichtex
- Gotax
- HPP
- Hamarin
- Hexanuret
- Ketanrift
- Ketobun-A
- Ledopur
- Lopurin
- Lysuron
- Milurit
- Miniplanor
- Monarch
- Nektrohan
- Progout
- Purinol
- Remid
- Riball
- Sigapurol
- Suspendol
- Takanarumin
- Urbol
- Uricemil
- Uriprim
- Uripurinol
- Uritas
- Urobenyl
- Urolit
- Urosin
- Urtias
- Urtias 100
- Xanturat
- Zyloprim
- Zyloric
Purinol Brand Names Mixture
- No information avaliable
Purinol Chemical_Formula
C5H4N4O
Purinol RX_link
http://www.rxlist.com/cgi/generic/allopur.htm
Purinol fda sheet
Purinol msds (material safety sheet)
Purinol Synthesis Reference
Robins, J. Am. Chem. So. 78, 784 (1956)
Purinol Molecular Weight
136.112 g/mol
Purinol Melting Point
350 oC
Purinol H2O Solubility
569 mg/L
Purinol State
Solid
Purinol LogP
-0.177
Purinol Dosage Forms
Tablet for oral administration (100mg, 200mg and 300mg); Injection
Purinol Indication
For the treatment of hyperuricemia associated with primary or secondary gout.
Purinol Pharmacology
Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid tumors.
Purinol Absorption
Approximately 90% absorbed from the gastrointestinal tract.
Purinol side effects and Toxicity
LD50=214 mg/kg (in mice)
Purinol Patient Information
Patients should be informed of the following:
- 1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth.
- 2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of allopurinol may be delayed for two to six weeks.
- 3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
- 4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the next scheduled time.
- 5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol, sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should follow the instructions of their physician.
- 6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory.
- 7. Patients may wish to take allopurinol after meals to minimize gastric irritation.
Purinol Organisms Affected
Humans and other mammals
