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Sigapurol Brand names, Sigapurol Analogs

Sigapurol Brand Names Mixture

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Sigapurol Chemical_Formula


Sigapurol RX_link

Sigapurol fda sheet

Sigapurol msds (material safety sheet)

Sigapurol MSDS

Sigapurol Synthesis Reference

Robins, J. Am. Chem. So. 78, 784 (1956)

Sigapurol Molecular Weight

136.112 g/mol

Sigapurol Melting Point

350 oC

Sigapurol H2O Solubility

569 mg/L

Sigapurol State


Sigapurol LogP


Sigapurol Dosage Forms

Tablet for oral administration (100mg, 200mg and 300mg); Injection

Sigapurol Indication

For the treatment of hyperuricemia associated with primary or secondary gout.

Sigapurol Pharmacology

Allopurinol, a structural analog of the natural purine base hypoxanthine, is used to prevent gout and renal calculi due to either uric acid or calcium oxalate and to treat uric acid nephropathy, hyperuricemia, and some solid tumors.

Sigapurol Absorption

Approximately 90% absorbed from the gastrointestinal tract.

Sigapurol side effects and Toxicity

LD50=214 mg/kg (in mice)

Sigapurol Patient Information

Patients should be informed of the following:

1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth.
2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of allopurinol may be delayed for two to six weeks.
3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the next scheduled time.
5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol, sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should follow the instructions of their physician.
6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory.
7. Patients may wish to take allopurinol after meals to minimize gastric irritation.

Sigapurol Organisms Affected

Humans and other mammals