Categorie
Ketanrift
Les marques,
Ketanrift
Analogs
Ketanrift
Les marques melange
No information avaliable
Ketanrift
Formule chimique
C5H4N4O
Ketanrift
RX lien
http://www.rxlist.com/cgi/generic/allopur.htm
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FDA fiche
Ketanrift
msds (fiche de securite des materiaux)
Ketanrift
Synthese de reference
Robins, J. Am. Chem. Alors. 78, 784 (1956)
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Poids moleculaire
136.112 g/mol
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Point de fusion
350 oC
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H2O Solubilite
569 mg / L
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Etat
Solid
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LogP
-0.177
Ketanrift
Formes pharmaceutiques
Tablette pour administration orale (100mg, 200mg et 300mg); Injection
Ketanrift
Indication
Pour le traitement de l'hyperuricémie associée à la goutte primaire ou secondaire.
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Pharmacologie
Allopurinol, un analogue structural de l'hypoxanthine naturels base purique, est utilisé pour prévenir la goutte et des calculs rénaux en raison soit de l'acide urique ou d'oxalate de calcium et de traiter la néphropathie acide urique, une hyperuricémie, et certaines tumeurs solides.
Ketanrift
Absorption
Environ 90% absorbés par le tractus gastro-intestinal.
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Toxicite
DL50 = 214 mg / kg (chez la souris)
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Information pour les patients
Patients should be informed of the following:
- 1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the
first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips
or mouth.
- 2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit
of allopurinol may be delayed for two to six weeks.
- 3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
- 4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the
next scheduled time.
- 5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol,
sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should
follow the instructions of their physician.
- 6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in
activities where alertness is mandatory.
- 7. Patients may wish to take allopurinol after meals to minimize gastric irritation.
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Organismes affectes
Les humains et autres mammifères