Categoria
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Nombres de marca,
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Analogos
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Marca los nombres de mezcla
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Formula quimica
C5H4N4O
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RX enlace
http://www.rxlist.com/cgi/generic/allopur.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
Robins, J. Am. Chem. Por lo tanto. 78, 784 (1956)
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Peso molecular
136.112 g/mol
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Punto de fusion
350 oC
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H2O Solubilidad
569 mg / L
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Estado
Solid
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LogP
-0.177
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Formas de dosificacion
Comprimido para administración oral (100 mg, 200 mg y 300 mg), inyección
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Indicacion
Para el tratamiento de la hiperuricemia asociados con la gota primaria o secundaria.
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Farmacologia
El alopurinol, un análogo estructural de la base de purina naturales hipoxantina, se utiliza para prevenir la gota y los cálculos renales debido a el ácido úrico o de oxalato de calcio y para el tratamiento de la nefropatía por ácido úrico, hiperuricemia, y algunos tumores sólidos.
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Absorcion
Aproximadamente el 90% es absorbido desde el tracto gastrointestinal.
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Toxicidad
LD50 = 214 mg / kg (en ratones)
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Informacion de Pacientes
Patients should be informed of the following:
- 1. They should be cautioned to discontinue allopurinol and to consult their physician immediately at the
first sign of a skin rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips
or mouth.
- 2. They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit
of allopurinol may be delayed for two to six weeks.
- 3. They should be encouraged to increase fluid intake during therapy to prevent renal stones.
- 4. If a single dose of allopurinol is occasionally forgotten, there is no need to double the dose at the
next scheduled time.
- 5. There may be certain risks associated with the concomitant use of allopurinol and dicumarol,
sulfinpyrazone, mercaptopurine, azathioprine, ampicillin, amoxicillin and thiazide diuretics, and they should
follow the instructions of their physician.
- 6. Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in
activities where alertness is mandatory.
- 7. Patients may wish to take allopurinol after meals to minimize gastric irritation.
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Organismos afectados
Humanos y otros mamíferos