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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C11H16N4O4
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RX_link
http://www.rxlist.com/cgi/generic2/dexrazoxane.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
268.269 g/mol
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Melting Point
191 - 197 oC
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H2O Solubility
Sparingly soluble
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State
Solid
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LogP
-2.135
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Dosage Forms
Liquid; Powder for solution
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Indication
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer.
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Pharmacology
Dexrazoxane is a cardioprotective agent for use in conjunction with doxorubicin indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose.
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Absorption
IV administration results in complete bioavailability.
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side effects and Toxicity
Intraperitoneal, mouse LD10 = 500 mg/kg. Intravenous, dog LD10 = 2 gm/kg.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals