Tepirone
Brand names,
Tepirone
Analogs
Tepirone
Brand Names Mixture
Tepirone
Chemical_Formula
C11H16N4O4
Tepirone
RX_link
http://www.rxlist.com/cgi/generic2/dexrazoxane.htm
Tepirone
fda sheet
Tepirone
msds (material safety sheet)
Tepirone
Synthesis Reference
No information avaliable
Tepirone
Molecular Weight
268.269 g/mol
Tepirone
Melting Point
191 - 197 oC
Tepirone
H2O Solubility
Sparingly soluble
Tepirone
State
Solid
Tepirone
LogP
-2.135
Tepirone
Dosage Forms
Liquid; Powder for solution
Tepirone
Indication
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer.
Tepirone
Pharmacology
Dexrazoxane is a cardioprotective agent for use in conjunction with doxorubicin indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose.
Tepirone
Absorption
IV administration results in complete bioavailability.
Tepirone
side effects and Toxicity
Intraperitoneal, mouse LD10 = 500 mg/kg. Intravenous, dog LD10 = 2 gm/kg.
Tepirone
Patient Information
No information avaliable
Tepirone
Organisms Affected
Humans and other mammals