Dextrorazoxane

Dextrorazoxane Brand names, Dextrorazoxane Analogs

Dextrorazoxane Brand Names Mixture

No information avaliable

Dextrorazoxane Chemical_Formula

C₁₁H₁₆N₄O₄

Dextrorazoxane RX_link

http://www.rxlist.com/cgi/generic2/dexrazoxane.htm

Dextrorazoxane fda sheet

Dextrorazoxane FDA

Dextrorazoxane msds (material safety sheet)

Dextrorazoxane MSDS

Dextrorazoxane Synthesis Reference

No information avaliable

Dextrorazoxane Molecular Weight

268.269 g/mol

Dextrorazoxane Melting Point

191 - 197 ^oC

Dextrorazoxane H₂O Solubility

Sparingly soluble

Dextrorazoxane State

Solid

Dextrorazoxane LogP

-2.135

Dextrorazoxane Dosage Forms

Liquid; Powder for solution

Dextrorazoxane Indication

For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer.

Dextrorazoxane Pharmacology

Dexrazoxane is a cardioprotective agent for use in conjunction with doxorubicin indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose.

Dextrorazoxane Absorption

IV administration results in complete bioavailability.

Dextrorazoxane side effects and Toxicity

Intraperitoneal, mouse LD₁₀ = 500 mg/kg. Intravenous, dog LD₁₀ = 2 gm/kg.

Dextrorazoxane Patient Information