Zesulan
Brand names,
Zesulan
Analogs
Zesulan
Brand Names Mixture
Zesulan
Chemical_Formula
C20H22N2S
Zesulan
RX_link
No information avaliable
Zesulan
fda sheet
Zesulan
msds (material safety sheet)
Zesulan
Synthesis Reference
G. Gueremy et al., Ger. pat. 2,009,555 corresp to U.S. pat. 3,987,042 (1970, 1976 to Sogeras)
Zesulan
Molecular Weight
322.468 g/mol
Zesulan
Melting Point
130.5 oC
Zesulan
H2O Solubility
No information avaliable
Zesulan
State
Solid
Zesulan
LogP
5.119
Zesulan
Dosage Forms
Tablet
Zesulan
Indication
For the treatment of Hay fever, urticaria (hives) and allergic rhinitis
Zesulan
Pharmacology
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Mequitazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Zesulan
Absorption
No information avaliable
Zesulan
side effects and Toxicity
No information avaliable
Zesulan
Patient Information
No information avaliable
Zesulan
Organisms Affected
Humans and other mammals