Instotal
Instotal Brand names, Instotal Analogs
Instotal Brand Names Mixture
- No information avaliable
Instotal Chemical_Formula
C20H22N2S
Instotal RX_link
No information avaliable
Instotal fda sheet
Instotal msds (material safety sheet)
Instotal Synthesis Reference
G. Gueremy et al., Ger. pat. 2,009,555 corresp to U.S. pat. 3,987,042 (1970, 1976 to Sogeras)
Instotal Molecular Weight
322.468 g/mol
Instotal Melting Point
130.5 oC
Instotal H2O Solubility
No information avaliable
Instotal State
Solid
Instotal LogP
5.119
Instotal Dosage Forms
Tablet
Instotal Indication
For the treatment of Hay fever, urticaria (hives) and allergic rhinitis
Instotal Pharmacology
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Mequitazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Instotal Absorption
No information avaliable
Instotal side effects and Toxicity
No information avaliable
Instotal Patient Information
No information avaliable
Instotal Organisms Affected
Humans and other mammals
