Vira-A
Vira-A Brand names, Vira-A Analogs
Vira-A Brand Names Mixture
- No information avaliable
Vira-A Chemical_Formula
C10H15N5O5
Vira-A RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Vira-A fda sheet
Vira-A msds (material safety sheet)
Vira-A Synthesis Reference
No information avaliable
Vira-A Molecular Weight
285.257 g/mol
Vira-A Melting Point
No information avaliable
Vira-A H2O Solubility
No information avaliable
Vira-A State
Solid
Vira-A LogP
-2.115
Vira-A Dosage Forms
No information avaliable
Vira-A Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Vira-A Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Vira-A Absorption
No information avaliable
Vira-A side effects and Toxicity
No information avaliable
Vira-A Patient Information
No information avaliable
Vira-A Organisms Affected
Human Herpes Viruses
