Vidarabin
Vidarabin Brand names, Vidarabin Analogs
Vidarabin Brand Names Mixture
- No information avaliable
Vidarabin Chemical_Formula
C10H15N5O5
Vidarabin RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Vidarabin fda sheet
Vidarabin msds (material safety sheet)
Vidarabin Synthesis Reference
No information avaliable
Vidarabin Molecular Weight
285.257 g/mol
Vidarabin Melting Point
No information avaliable
Vidarabin H2O Solubility
No information avaliable
Vidarabin State
Solid
Vidarabin LogP
-2.115
Vidarabin Dosage Forms
No information avaliable
Vidarabin Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Vidarabin Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Vidarabin Absorption
No information avaliable
Vidarabin side effects and Toxicity
No information avaliable
Vidarabin Patient Information
No information avaliable
Vidarabin Organisms Affected
Human Herpes Viruses
