Ara-Atp en es it fr

Ara-Atp Brand names, Ara-Atp Analogs

Ara-Atp Brand Names Mixture

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Ara-Atp Chemical_Formula


Ara-Atp RX_link

Ara-Atp fda sheet

Ara-Atp msds (material safety sheet)

Ara-Atp Synthesis Reference

No information avaliable

Ara-Atp Molecular Weight

285.257 g/mol

Ara-Atp Melting Point

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Ara-Atp H2O Solubility

No information avaliable

Ara-Atp State


Ara-Atp LogP


Ara-Atp Dosage Forms

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Ara-Atp Indication

For treatment of chickenpox - varicella, herpes zoster and herpes simplex

Ara-Atp Pharmacology

Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.

Ara-Atp Absorption

No information avaliable

Ara-Atp side effects and Toxicity

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Ara-Atp Patient Information

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Ara-Atp Organisms Affected

Human Herpes Viruses