Ara-Atp
Ara-Atp Brand names, Ara-Atp Analogs
Ara-Atp Brand Names Mixture
- No information avaliable
Ara-Atp Chemical_Formula
C10H15N5O5
Ara-Atp RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Ara-Atp fda sheet
Ara-Atp msds (material safety sheet)
Ara-Atp Synthesis Reference
No information avaliable
Ara-Atp Molecular Weight
285.257 g/mol
Ara-Atp Melting Point
No information avaliable
Ara-Atp H2O Solubility
No information avaliable
Ara-Atp State
Solid
Ara-Atp LogP
-2.115
Ara-Atp Dosage Forms
No information avaliable
Ara-Atp Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Ara-Atp Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Ara-Atp Absorption
No information avaliable
Ara-Atp side effects and Toxicity
No information avaliable
Ara-Atp Patient Information
No information avaliable
Ara-Atp Organisms Affected
Human Herpes Viruses
