Arabinosyl-Atp en es it fr

Arabinosyl-Atp Brand names, Arabinosyl-Atp Analogs

Arabinosyl-Atp Brand Names Mixture

  • No information avaliable

Arabinosyl-Atp Chemical_Formula

C10H15N5O5

Arabinosyl-Atp RX_link

http://www.rxlist.com/cgi/generic3/vidarabine.htm

Arabinosyl-Atp fda sheet

Arabinosyl-Atp msds (material safety sheet)

Arabinosyl-Atp Synthesis Reference

No information avaliable

Arabinosyl-Atp Molecular Weight

285.257 g/mol

Arabinosyl-Atp Melting Point

No information avaliable

Arabinosyl-Atp H2O Solubility

No information avaliable

Arabinosyl-Atp State

Solid

Arabinosyl-Atp LogP

-2.115

Arabinosyl-Atp Dosage Forms

No information avaliable

Arabinosyl-Atp Indication

For treatment of chickenpox - varicella, herpes zoster and herpes simplex

Arabinosyl-Atp Pharmacology

Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.

Arabinosyl-Atp Absorption

No information avaliable

Arabinosyl-Atp side effects and Toxicity

No information avaliable

Arabinosyl-Atp Patient Information

No information avaliable

Arabinosyl-Atp Organisms Affected

Human Herpes Viruses