Arabinoside Adenine
Arabinoside Adenine Brand names, Arabinoside Adenine Analogs
Arabinoside Adenine Brand Names Mixture
- No information avaliable
Arabinoside Adenine Chemical_Formula
C10H15N5O5
Arabinoside Adenine RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Arabinoside Adenine fda sheet
Arabinoside Adenine msds (material safety sheet)
Arabinoside Adenine Synthesis Reference
No information avaliable
Arabinoside Adenine Molecular Weight
285.257 g/mol
Arabinoside Adenine Melting Point
No information avaliable
Arabinoside Adenine H2O Solubility
No information avaliable
Arabinoside Adenine State
Solid
Arabinoside Adenine LogP
-2.115
Arabinoside Adenine Dosage Forms
No information avaliable
Arabinoside Adenine Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Arabinoside Adenine Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Arabinoside Adenine Absorption
No information avaliable
Arabinoside Adenine side effects and Toxicity
No information avaliable
Arabinoside Adenine Patient Information
No information avaliable
Arabinoside Adenine Organisms Affected
Human Herpes Viruses
