Arabinosyl Adenine
Arabinosyl Adenine Brand names, Arabinosyl Adenine Analogs
Arabinosyl Adenine Brand Names Mixture
- No information avaliable
Arabinosyl Adenine Chemical_Formula
C10H15N5O5
Arabinosyl Adenine RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Arabinosyl Adenine fda sheet
Arabinosyl Adenine msds (material safety sheet)
Arabinosyl Adenine Synthesis Reference
No information avaliable
Arabinosyl Adenine Molecular Weight
285.257 g/mol
Arabinosyl Adenine Melting Point
No information avaliable
Arabinosyl Adenine H2O Solubility
No information avaliable
Arabinosyl Adenine State
Solid
Arabinosyl Adenine LogP
-2.115
Arabinosyl Adenine Dosage Forms
No information avaliable
Arabinosyl Adenine Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Arabinosyl Adenine Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Arabinosyl Adenine Absorption
No information avaliable
Arabinosyl Adenine side effects and Toxicity
No information avaliable
Arabinosyl Adenine Patient Information
No information avaliable
Arabinosyl Adenine Organisms Affected
Human Herpes Viruses
