Vidarabine Triphosphate
Vidarabine Triphosphate Brand names, Vidarabine Triphosphate Analogs
Vidarabine Triphosphate Brand Names Mixture
- No information avaliable
Vidarabine Triphosphate Chemical_Formula
C10H15N5O5
Vidarabine Triphosphate RX_link
http://www.rxlist.com/cgi/generic3/vidarabine.htm
Vidarabine Triphosphate fda sheet
Vidarabine Triphosphate msds (material safety sheet)
Vidarabine Triphosphate Synthesis Reference
No information avaliable
Vidarabine Triphosphate Molecular Weight
285.257 g/mol
Vidarabine Triphosphate Melting Point
No information avaliable
Vidarabine Triphosphate H2O Solubility
No information avaliable
Vidarabine Triphosphate State
Solid
Vidarabine Triphosphate LogP
-2.115
Vidarabine Triphosphate Dosage Forms
No information avaliable
Vidarabine Triphosphate Indication
For treatment of chickenpox - varicella, herpes zoster and herpes simplex
Vidarabine Triphosphate Pharmacology
Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.
Vidarabine Triphosphate Absorption
No information avaliable
Vidarabine Triphosphate side effects and Toxicity
No information avaliable
Vidarabine Triphosphate Patient Information
No information avaliable
Vidarabine Triphosphate Organisms Affected
Human Herpes Viruses
