Synthetic gonadoliberin
Brand names,
Synthetic gonadoliberin
Analogs
Synthetic gonadoliberin
Brand Names Mixture
Synthetic gonadoliberin
Chemical_Formula
(FeO.OH.2H2O)478 (Dx.COOH)9
Synthetic gonadoliberin
RX_link
http://www.rxlist.com/cgi/generic3/fedex.htm
Synthetic gonadoliberin
fda sheet
Synthetic gonadoliberin
msds (material safety sheet)
Synthetic gonadoliberin
Synthesis Reference
No information avaliable
Synthetic gonadoliberin
Molecular Weight
105000 g/mol (average)
Synthetic gonadoliberin
Melting Point
No information avaliable
Synthetic gonadoliberin
H2O Solubility
Soluble
Synthetic gonadoliberin
State
Solid
Synthetic gonadoliberin
LogP
No information avaliable
Synthetic gonadoliberin
Dosage Forms
Solution (for intramuscular injection)
Synthetic gonadoliberin
Indication
For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
Synthetic gonadoliberin
Pharmacology
Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Iron is essential to the formation of hemoglobin and to the function and formation of other heme and nonheme compounds. Untreated depletion of iron stores leads to iron-deficient erythropoiesis and, in turn, to iron deficiency anemia.
Synthetic gonadoliberin
Absorption
The major portion of intramuscular injections of iron dextran is absorbed within 72 hours; most of the remaining iron is absorbed over the ensuing 3 to 4 weeks.
Synthetic gonadoliberin
side effects and Toxicity
LD50 = 500 mg/kg (mouse, IV). Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Cases of severe, sometimes fatal, allergic reactions (loss of consciousness, collapse, difficulty breathing, hives, swelling, or convulsions) and severe low blood pressure (hypotension) have been reported with the use of iron dextran.
Synthetic gonadoliberin
Patient Information
http://www.drugs.com/cons/Inulin.html
Synthetic gonadoliberin
Organisms Affected
Humans and other mammals