Synthetic LH-RF
Brand names,
Synthetic LH-RF
Analogs
Synthetic LH-RF
Brand Names Mixture
Synthetic LH-RF
Chemical_Formula
(FeO.OH.2H2O)478 (Dx.COOH)9
Synthetic LH-RF
RX_link
http://www.rxlist.com/cgi/generic3/fedex.htm
Synthetic LH-RF
fda sheet
Synthetic LH-RF
msds (material safety sheet)
Synthetic LH-RF
Synthesis Reference
No information avaliable
Synthetic LH-RF
Molecular Weight
105000 g/mol (average)
Synthetic LH-RF
Melting Point
No information avaliable
Synthetic LH-RF
H2O Solubility
Soluble
Synthetic LH-RF
State
Solid
Synthetic LH-RF
LogP
No information avaliable
Synthetic LH-RF
Dosage Forms
Solution (for intramuscular injection)
Synthetic LH-RF
Indication
For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
Synthetic LH-RF
Pharmacology
Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Iron is essential to the formation of hemoglobin and to the function and formation of other heme and nonheme compounds. Untreated depletion of iron stores leads to iron-deficient erythropoiesis and, in turn, to iron deficiency anemia.
Synthetic LH-RF
Absorption
The major portion of intramuscular injections of iron dextran is absorbed within 72 hours; most of the remaining iron is absorbed over the ensuing 3 to 4 weeks.
Synthetic LH-RF
side effects and Toxicity
LD50 = 500 mg/kg (mouse, IV). Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Cases of severe, sometimes fatal, allergic reactions (loss of consciousness, collapse, difficulty breathing, hives, swelling, or convulsions) and severe low blood pressure (hypotension) have been reported with the use of iron dextran.
Synthetic LH-RF
Patient Information
http://www.drugs.com/cons/Inulin.html
Synthetic LH-RF
Organisms Affected
Humans and other mammals