Sulfametopyrazine
Brand names,
Sulfametopyrazine
Analogs
Sulfametopyrazine
Brand Names Mixture
Sulfametopyrazine
Chemical_Formula
C11H12N4O3S
Sulfametopyrazine
RX_link
No information avaliable
Sulfametopyrazine
fda sheet
Sulfametopyrazine
msds (material safety sheet)
Sulfametopyrazine
Synthesis Reference
No information avaliable
Sulfametopyrazine
Molecular Weight
280.304 g/mol
Sulfametopyrazine
Melting Point
169.5 oC
Sulfametopyrazine
H2O Solubility
4030 mg/L
Sulfametopyrazine
State
Solid
Sulfametopyrazine
LogP
1.441
Sulfametopyrazine
Dosage Forms
Tablet
Sulfametopyrazine
Indication
For the treatment of urinary tract infection and chronic bronchitis.
Sulfametopyrazine
Pharmacology
Sulfametopyrazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfametopyrazine
Absorption
No information avaliable
Sulfametopyrazine
side effects and Toxicity
No information avaliable
Sulfametopyrazine
Patient Information
Sulfametopyrazine
Organisms Affected
Gram negative, positive bacteria and plasmodium