Farmitalia 204/122
Brand names,
Farmitalia 204/122
Analogs
Farmitalia 204/122
Brand Names Mixture
Farmitalia 204/122
Chemical_Formula
C11H12N4O3S
Farmitalia 204/122
RX_link
No information avaliable
Farmitalia 204/122
fda sheet
Farmitalia 204/122
msds (material safety sheet)
Farmitalia 204/122
Synthesis Reference
No information avaliable
Farmitalia 204/122
Molecular Weight
280.304 g/mol
Farmitalia 204/122
Melting Point
169.5 oC
Farmitalia 204/122
H2O Solubility
4030 mg/L
Farmitalia 204/122
State
Solid
Farmitalia 204/122
LogP
1.441
Farmitalia 204/122
Dosage Forms
Tablet
Farmitalia 204/122
Indication
For the treatment of urinary tract infection and chronic bronchitis.
Farmitalia 204/122
Pharmacology
Sulfametopyrazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Farmitalia 204/122
Absorption
No information avaliable
Farmitalia 204/122
side effects and Toxicity
No information avaliable
Farmitalia 204/122
Patient Information
Farmitalia 204/122
Organisms Affected
Gram negative, positive bacteria and plasmodium