Rifampicin Sv
Brand names,
Rifampicin Sv
Analogs
Rifampicin Sv
Brand Names Mixture
- Rifater (Isoniazid + Pyrazinaamide + Rifampin)
- Rifamate (Rifampin + Isoniazid)
Rifampicin Sv
Chemical_Formula
C43H58N4O12
Rifampicin Sv
RX_link
http://www.rxlist.com/cgi/generic2/rifampin.htm
Rifampicin Sv
fda sheet
Rifampicin Sv
msds (material safety sheet)
Rifampicin Sv
Synthesis Reference
No information avaliable
Rifampicin Sv
Molecular Weight
822.94 g/mol
Rifampicin Sv
Melting Point
183 oC
Rifampicin Sv
H2O Solubility
1.4 mg/mL
Rifampicin Sv
State
Solid
Rifampicin Sv
LogP
3.719
Rifampicin Sv
Dosage Forms
Capsule
Rifampicin Sv
Indication
For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
Rifampicin Sv
Pharmacology
Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Rifampicin Sv
Absorption
Well absorbed from gastrointestinal tract.
Rifampicin Sv
side effects and Toxicity
LD50=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness
Rifampicin Sv
Patient Information
The patient should be told that rifampin may produce a reddish coloration of the urine, sweat, sputum, and tears,
and the patient should be forewarned of this. Soft contact lenses may be permanently stained. The patients should be
advised that the reliability of oral or other systemic hormonal contraceptives may be affected; consideration should
be given to using alternative contraceptive measures. Patients should be instructed to take rifampin either 1 hour
before or 2 hours after a meal with a full glass of water. Patients should be instructed to notify their physicians
promptly if they experience any of the following: fever, loss of appetite, malaise, nausea and vomiting, darkened
urine, yellowish discoloration of the skin and eyes, and pain or swelling of the joints. Compliance with the full
course of therapy must be emphasized, and the importance of not missing any doses must be stressed.
Rifampicin Sv
Organisms Affected
Mycobacteria and a variety of other gram negative and gram postivie bacteria