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Rimactin Brand names, Rimactin Analogs

Rimactin Brand Names Mixture

  • Rifater (Isoniazid + Pyrazinaamide + Rifampin)
  • Rifamate (Rifampin + Isoniazid)

Rimactin Chemical_Formula


Rimactin RX_link


Rimactin fda sheet

Rimactin FDA

Rimactin msds (material safety sheet)

Rimactin MSDS

Rimactin Synthesis Reference

No information avaliable

Rimactin Molecular Weight

822.94 g/mol

Rimactin Melting Point

183 oC

Rimactin H2O Solubility

1.4 mg/mL

Rimactin State


Rimactin LogP


Rimactin Dosage Forms


Rimactin Indication

For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

Rimactin Pharmacology

Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Rimactin Absorption

Well absorbed from gastrointestinal tract.

Rimactin side effects and Toxicity

LD50=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness

Rimactin Patient Information

The patient should be told that rifampin may produce a reddish coloration of the urine, sweat, sputum, and tears, and the patient should be forewarned of this. Soft contact lenses may be permanently stained. The patients should be advised that the reliability of oral or other systemic hormonal contraceptives may be affected; consideration should be given to using alternative contraceptive measures. Patients should be instructed to take rifampin either 1 hour before or 2 hours after a meal with a full glass of water. Patients should be instructed to notify their physicians promptly if they experience any of the following: fever, loss of appetite, malaise, nausea and vomiting, darkened urine, yellowish discoloration of the skin and eyes, and pain or swelling of the joints. Compliance with the full course of therapy must be emphasized, and the importance of not missing any doses must be stressed.

Rimactin Organisms Affected

Mycobacteria and a variety of other gram negative and gram postivie bacteria