Rifa
Rifa Brand names, Rifa Analogs
Rifa Brand Names Mixture
- No information avaliable
Rifa Chemical_Formula
C46H62N4O11
Rifa RX_link
http://www.rxlist.com/cgi/generic2/rifabutin.htm
Rifa fda sheet
Rifa msds (material safety sheet)
Rifa Synthesis Reference
No information avaliable
Rifa Molecular Weight
847.005 g/mol
Rifa Melting Point
No information avaliable
Rifa H2O Solubility
Minimally soluble (0.19 mg/mL)
Rifa State
Solid
Rifa LogP
4.218
Rifa Dosage Forms
Capsule
Rifa Indication
For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.
Rifa Pharmacology
Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Rifa Absorption
Rifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%.
Rifa side effects and Toxicity
LD50 = 4.8 g/kg (mouse, male)
Rifa Patient Information
Patients should be advised of the signs and symptoms of both MAC and tuberculosis, and should be instructed to consult their physicians if they develop new complaints consistent with either of these diseases. In addition, since MYCOBUTIN may rarely be associated with myositis and uveitis, patients should be advised to notify their physicians if they develop signs or symptoms suggesting either of these disorders.
Urine, feces, saliva, sputum, perspiration, tears, and skin may be colored brown-orange with rifabutin and some of its metabolites. Soft contact lenses may be permanently stained. Patients to be treated with MYCOBUTIN should be made aware of these possibilities.
Rifa Organisms Affected
Enteric bacteria and other eubacteria
