L-5103 Lepetit
Brand names,
L-5103 Lepetit
Analogs
L-5103 Lepetit
Brand Names Mixture
- Rifater (Isoniazid + Pyrazinaamide + Rifampin)
- Rifamate (Rifampin + Isoniazid)
L-5103 Lepetit
Chemical_Formula
C43H58N4O12
L-5103 Lepetit
RX_link
http://www.rxlist.com/cgi/generic2/rifampin.htm
L-5103 Lepetit
fda sheet
L-5103 Lepetit
msds (material safety sheet)
L-5103 Lepetit
Synthesis Reference
No information avaliable
L-5103 Lepetit
Molecular Weight
822.94 g/mol
L-5103 Lepetit
Melting Point
183 oC
L-5103 Lepetit
H2O Solubility
1.4 mg/mL
L-5103 Lepetit
State
Solid
L-5103 Lepetit
LogP
3.719
L-5103 Lepetit
Dosage Forms
Capsule
L-5103 Lepetit
Indication
For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
L-5103 Lepetit
Pharmacology
Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
L-5103 Lepetit
Absorption
Well absorbed from gastrointestinal tract.
L-5103 Lepetit
side effects and Toxicity
LD50=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness
L-5103 Lepetit
Patient Information
The patient should be told that rifampin may produce a reddish coloration of the urine, sweat, sputum, and tears,
and the patient should be forewarned of this. Soft contact lenses may be permanently stained. The patients should be
advised that the reliability of oral or other systemic hormonal contraceptives may be affected; consideration should
be given to using alternative contraceptive measures. Patients should be instructed to take rifampin either 1 hour
before or 2 hours after a meal with a full glass of water. Patients should be instructed to notify their physicians
promptly if they experience any of the following: fever, loss of appetite, malaise, nausea and vomiting, darkened
urine, yellowish discoloration of the skin and eyes, and pain or swelling of the joints. Compliance with the full
course of therapy must be emphasized, and the importance of not missing any doses must be stressed.
L-5103 Lepetit
Organisms Affected
Mycobacteria and a variety of other gram negative and gram postivie bacteria