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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H18F3NO
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RX_link
http://www.rxlist.com/cgi/generic/fluoxetine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
B. B. Mally; K. K. Schmiegel; U.S. Pat. 4,314,081 (1982)
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Molecular Weight
309.326 g/mol
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Melting Point
179-182oC
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H2O Solubility
50 mg/mL at 25°C
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State
Solid
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LogP
5.37
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Dosage Forms
Capsule; Liquid; Solution
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Indication
For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.
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Pharmacology
Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.
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Absorption
72%
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side effects and Toxicity
Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD50=284mg/kg (orally in mice).
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Patient Information
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Organisms Affected
Humans and other mammals