Foxetin
Brand names,
Foxetin
Analogs
Foxetin
Brand Names Mixture
Foxetin
Chemical_Formula
C17H18F3NO
Foxetin
RX_link
http://www.rxlist.com/cgi/generic/fluoxetine.htm
Foxetin
fda sheet
Foxetin
msds (material safety sheet)
Foxetin
Synthesis Reference
B. B. Mally; K. K. Schmiegel; U.S. Pat. 4,314,081 (1982)
Foxetin
Molecular Weight
309.326 g/mol
Foxetin
Melting Point
179-182oC
Foxetin
H2O Solubility
50 mg/mL at 25°C
Foxetin
State
Solid
Foxetin
LogP
5.37
Foxetin
Dosage Forms
Capsule; Liquid; Solution
Foxetin
Indication
For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.
Foxetin
Pharmacology
Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.
Foxetin
Absorption
72%
Foxetin
side effects and Toxicity
Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD50=284mg/kg (orally in mice).
Foxetin
Patient Information
Foxetin
Organisms Affected
Humans and other mammals