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• Antidepressants, Second-Generation
• Selective Serotonin Reuptake Inhibitors (SSRIs)
• ATC:N06AB03

• Animex-On
• Deprex
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• Fluoxeren
• Fluoxetina [Inn-Spanish]
• Fluoxetina [Spanish]
• Fluoxetine Hcl
• Fluoxetine Hydrochloride
• Fluoxetine Hydrochloride: Adofen
• Fluoxetinum [Inn-Latin]
• Fluval
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C₁₇H₁₈F₃NO

http://www.rxlist.com/cgi/generic/fluoxetine.htm

Portal FDA

Portal MSDS

B. B. Mally; K. K. Schmiegel; U.S. Pat. 4,314,081 (1982)

309.326 g/mol

179-182^oC

50 mg/mL at 25°C

Solid

5.37

Capsule; Liquid; Solution

For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.

Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.

72%

Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD₅₀=284mg/kg (orally in mice).

Humans and other mammals