Fluoxetine Hcl
Brand names,
Fluoxetine Hcl
Analogs
Fluoxetine Hcl
Brand Names Mixture
Fluoxetine Hcl
Chemical_Formula
C17H18F3NO
Fluoxetine Hcl
RX_link
http://www.rxlist.com/cgi/generic/fluoxetine.htm
Fluoxetine Hcl
fda sheet
Fluoxetine Hcl
msds (material safety sheet)
Fluoxetine Hcl
Synthesis Reference
B. B. Mally; K. K. Schmiegel; U.S. Pat. 4,314,081 (1982)
Fluoxetine Hcl
Molecular Weight
309.326 g/mol
Fluoxetine Hcl
Melting Point
179-182oC
Fluoxetine Hcl
H2O Solubility
50 mg/mL at 25°C
Fluoxetine Hcl
State
Solid
Fluoxetine Hcl
LogP
5.37
Fluoxetine Hcl
Dosage Forms
Capsule; Liquid; Solution
Fluoxetine Hcl
Indication
For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.
Fluoxetine Hcl
Pharmacology
Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.
Fluoxetine Hcl
Absorption
72%
Fluoxetine Hcl
side effects and Toxicity
Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD50=284mg/kg (orally in mice).
Fluoxetine Hcl
Patient Information
Fluoxetine Hcl
Organisms Affected
Humans and other mammals