Fluval
Brand names,
Fluval
Analogs
Fluval
Brand Names Mixture
Fluval
Chemical_Formula
C17H18F3NO
Fluval
RX_link
http://www.rxlist.com/cgi/generic/fluoxetine.htm
Fluval
fda sheet
Fluval
msds (material safety sheet)
Fluval
Synthesis Reference
B. B. Mally; K. K. Schmiegel; U.S. Pat. 4,314,081 (1982)
Fluval
Molecular Weight
309.326 g/mol
Fluval
Melting Point
179-182oC
Fluval
H2O Solubility
50 mg/mL at 25°C
Fluval
State
Solid
Fluval
LogP
5.37
Fluval
Dosage Forms
Capsule; Liquid; Solution
Fluval
Indication
For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.
Fluval
Pharmacology
Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.
Fluval
Absorption
72%
Fluval
side effects and Toxicity
Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD50=284mg/kg (orally in mice).
Fluval
Patient Information
Fluval
Organisms Affected
Humans and other mammals