Prosom
Prosom Brand names, Prosom Analogs
Prosom Brand Names Mixture
- No information avaliable
Prosom Chemical_Formula
C8H10N2S
Prosom RX_link
http://www.rxlist.com/cgi/generic2/ethionamide.htm
Prosom fda sheet
Prosom msds (material safety sheet)
Prosom Synthesis Reference
No information avaliable
Prosom Molecular Weight
166.244 g/mol
Prosom Melting Point
163 oC
Prosom H2O Solubility
Practically insoluble
Prosom State
Solid
Prosom LogP
0.705
Prosom Dosage Forms
Tablet (250 mg)
Prosom Indication
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Prosom Pharmacology
Ethinamate is bacteriostatic against M. tuberculosis. In a study examining ethionamide resistance, ethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected mice. Drug resistance developed with continued ethionamide monotherapy, but did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
Prosom Absorption
Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
Prosom side effects and Toxicity
Symptoms of overdose include convulsions, nausea, and vomiting.
Prosom Patient Information
No information avaliable
Prosom Organisms Affected
Mycobacteria
