Julodin
Julodin Brand names, Julodin Analogs
Julodin Brand Names Mixture
- No information avaliable
Julodin Chemical_Formula
C8H10N2S
Julodin RX_link
http://www.rxlist.com/cgi/generic2/ethionamide.htm
Julodin fda sheet
Julodin msds (material safety sheet)
Julodin Synthesis Reference
No information avaliable
Julodin Molecular Weight
166.244 g/mol
Julodin Melting Point
163 oC
Julodin H2O Solubility
Practically insoluble
Julodin State
Solid
Julodin LogP
0.705
Julodin Dosage Forms
Tablet (250 mg)
Julodin Indication
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Julodin Pharmacology
Ethinamate is bacteriostatic against M. tuberculosis. In a study examining ethionamide resistance, ethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected mice. Drug resistance developed with continued ethionamide monotherapy, but did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
Julodin Absorption
Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
Julodin side effects and Toxicity
Symptoms of overdose include convulsions, nausea, and vomiting.
Julodin Patient Information
No information avaliable
Julodin Organisms Affected
Mycobacteria
