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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C8H10N2S
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RX_link
http://www.rxlist.com/cgi/generic2/ethionamide.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
166.244 g/mol
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Melting Point
163 oC
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H2O Solubility
Practically insoluble
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State
Solid
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LogP
0.705
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Dosage Forms
Tablet (250 mg)
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Indication
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
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Pharmacology
Ethinamate is bacteriostatic against M. tuberculosis. In a study examining ethionamide resistance, ethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected mice. Drug resistance developed with continued ethionamide monotherapy, but did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
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Absorption
Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
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side effects and Toxicity
Symptoms of overdose include convulsions, nausea, and vomiting.
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Patient Information
No information avaliable
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Organisms Affected
Mycobacteria