Esilgan
Esilgan Brand names, Esilgan Analogs
Esilgan Brand Names Mixture
- No information avaliable
Esilgan Chemical_Formula
C8H10N2S
Esilgan RX_link
http://www.rxlist.com/cgi/generic2/ethionamide.htm
Esilgan fda sheet
Esilgan msds (material safety sheet)
Esilgan Synthesis Reference
No information avaliable
Esilgan Molecular Weight
166.244 g/mol
Esilgan Melting Point
163 oC
Esilgan H2O Solubility
Practically insoluble
Esilgan State
Solid
Esilgan LogP
0.705
Esilgan Dosage Forms
Tablet (250 mg)
Esilgan Indication
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Esilgan Pharmacology
Ethinamate is bacteriostatic against M. tuberculosis. In a study examining ethionamide resistance, ethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected mice. Drug resistance developed with continued ethionamide monotherapy, but did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
Esilgan Absorption
Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
Esilgan side effects and Toxicity
Symptoms of overdose include convulsions, nausea, and vomiting.
Esilgan Patient Information
No information avaliable
Esilgan Organisms Affected
Mycobacteria
