D 40TA
D 40TA Brand names, D 40TA Analogs
D 40TA Brand Names Mixture
- No information avaliable
D 40TA Chemical_Formula
C8H10N2S
D 40TA RX_link
http://www.rxlist.com/cgi/generic2/ethionamide.htm
D 40TA fda sheet
D 40TA msds (material safety sheet)
D 40TA Synthesis Reference
No information avaliable
D 40TA Molecular Weight
166.244 g/mol
D 40TA Melting Point
163 oC
D 40TA H2O Solubility
Practically insoluble
D 40TA State
Solid
D 40TA LogP
0.705
D 40TA Dosage Forms
Tablet (250 mg)
D 40TA Indication
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
D 40TA Pharmacology
Ethinamate is bacteriostatic against M. tuberculosis. In a study examining ethionamide resistance, ethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected mice. Drug resistance developed with continued ethionamide monotherapy, but did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
D 40TA Absorption
Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
D 40TA side effects and Toxicity
Symptoms of overdose include convulsions, nausea, and vomiting.
D 40TA Patient Information
No information avaliable
D 40TA Organisms Affected
Mycobacteria
