Nuctalon
Nuctalon Brand names, Nuctalon Analogs
Nuctalon Brand Names Mixture
- No information avaliable
Nuctalon Chemical_Formula
C8H10N2S
Nuctalon RX_link
http://www.rxlist.com/cgi/generic2/ethionamide.htm
Nuctalon fda sheet
Nuctalon msds (material safety sheet)
Nuctalon Synthesis Reference
No information avaliable
Nuctalon Molecular Weight
166.244 g/mol
Nuctalon Melting Point
163 oC
Nuctalon H2O Solubility
Practically insoluble
Nuctalon State
Solid
Nuctalon LogP
0.705
Nuctalon Dosage Forms
Tablet (250 mg)
Nuctalon Indication
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Nuctalon Pharmacology
Ethinamate is bacteriostatic against M. tuberculosis. In a study examining ethionamide resistance, ethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected mice. Drug resistance developed with continued ethionamide monotherapy, but did not occur when mice received ethionamide in combination with streptomycin or isoniazid.
Nuctalon Absorption
Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
Nuctalon side effects and Toxicity
Symptoms of overdose include convulsions, nausea, and vomiting.
Nuctalon Patient Information
No information avaliable
Nuctalon Organisms Affected
Mycobacteria
