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Prink Brand names, Prink Analogs

Prink Brand Names Mixture

  • No information avaliable

Prink Chemical_Formula


Prink RX_link

Prink fda sheet

Prink FDA

Prink msds (material safety sheet)

Prink MSDS

Prink Synthesis Reference

No information avaliable

Prink Molecular Weight

354.481 g/mol

Prink Melting Point

115 - 116 oC

Prink H2O Solubility

26.7 mg/L

Prink State


Prink LogP


Prink Dosage Forms

Liquid; Powder for solution; Solution; Suppository

Prink Indication

For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Prink Pharmacology

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.

Prink Absorption

The absolute bioavailability of alprostadil has not been determined.

Prink side effects and Toxicity

Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.

Prink Patient Information

Prink Organisms Affected

Humans and other mammals