Muse
Muse Brand names, Muse Analogs
Muse Brand Names Mixture
- No information avaliable
Muse Chemical_Formula
C20H34O5
Muse RX_link
http://www.rxlist.com/cgi/generic/alprostadil.htm
Muse fda sheet
Muse msds (material safety sheet)
Muse Synthesis Reference
No information avaliable
Muse Molecular Weight
354.481 g/mol
Muse Melting Point
115 - 116 oC
Muse H2O Solubility
26.7 mg/L
Muse State
Solid
Muse LogP
2.983
Muse Dosage Forms
Liquid; Powder for solution; Solution; Suppository
Muse Indication
For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Muse Pharmacology
Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.
Muse Absorption
The absolute bioavailability of alprostadil has not been determined.
Muse side effects and Toxicity
Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.
Muse Patient Information
Muse Organisms Affected
Humans and other mammals
