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Edex Brand names, Edex Analogs

Edex Brand Names Mixture

  • No information avaliable

Edex Chemical_Formula


Edex RX_link


Edex fda sheet

Edex FDA

Edex msds (material safety sheet)


Edex Synthesis Reference

No information avaliable

Edex Molecular Weight

354.481 g/mol

Edex Melting Point

115 - 116 oC

Edex H2O Solubility

26.7 mg/L

Edex State


Edex LogP


Edex Dosage Forms

Liquid; Powder for solution; Solution; Suppository

Edex Indication

For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Edex Pharmacology

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.

Edex Absorption

The absolute bioavailability of alprostadil has not been determined.

Edex side effects and Toxicity

Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.

Edex Patient Information

Edex Organisms Affected

Humans and other mammals